Telomere attrition as a biomarker in a welfare context?
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منابع مشابه
Cumulative stress in research animals: Telomere attrition as a biomarker in a welfare context?
Progress in improving animal welfare is currently limited by the lack of objective methods for assessing lifetime experience. I propose that telomere attrition, a cellular biomarker of biological age, provides a molecular measure of cumulative experience that could be used to assess the welfare impact of husbandry regimes and/or experimental procedures on non-human animals. I review evidence fr...
متن کاملStudying telomeres in a longitudinal population based study.
Telomeres, the termini of linear chromosomes, consist of large but variable numbers of DNA oligomer repeats embedded in a nucleoprotein complex. In humans, telomere length (TL) is largely genetically determined but also featured by an age dependent attrition. TL has therefore been put forward as a marker for biological aging and was also reported to be associated with aging diseases such as car...
متن کاملTelomere Attrition Due to Infection
BACKGROUND Telomeres--the terminal caps of chromosomes--become shorter as individuals age, and there is much interest in determining what causes telomere attrition since this process may play a role in biological aging. The leading hypothesis is that telomere attrition is due to inflammation, exposure to infectious agents, and other types of oxidative stress, which damage telomeres and impair t...
متن کاملDevelopmental telomere attrition predicts impulsive decision-making in adult starlings
Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits. We tested the prediction that if, as has been suggested, developmental telomere attrition is a biomarker of state and future life expectancy, then individuals who have undergone greater developmental telomere att...
متن کاملBlood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
BACKGROUND Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS We included 792 Normative Aging Study participants with 1-4 BTL measurements from 1999 to 2012. We used...
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تاریخ انتشار 2015